407 ‒ Preventing cardiovascular and Alzheimer’s disease: lowering LDL early, APOE4, and more

Michael Davidson is a world-renowned cardiologist, lipidologist, and the founding CEO of NewAmsterdam Pharma. He begins this episode by sharing how his family history shaped his interest in lipidology and primary prevention. He explains why prevention should focus on causal drivers of disease rather than near-term risk and examines the causal relationship between LDL and atherosclerotic cardiovascular disease. 0:00:00 - Intro 0:00:11 - Michael’s path to lipidology, and his passion for primary prevention 0:07:54 - Reframing prevention around causal drivers rather than time horizon 0:14:11 - Wha